Skullcap aerial parts extract comes from the above-ground portions of the American skullcap plant (*Scutellaria lateriflora*). People prepare it as a tea, tincture, or encapsulated extract. Unlike Chinese skullcap (*Scutellaria baicalensis*), which supplies baicalin, American skullcap provides flavonoids like scutellarin. Traditional use centers on calming the nervous system.
Many people take it for mild, occasional stress or to feel more at ease. At moderate doses, it does not usually cause drowsiness. Some prefer it during daytime hours rather than only at bedtime.
The chemical makeup of skullcap products can vary. Differences arise from harvest time, extraction method, and whether the product is standardized. Pregnant or nursing women should avoid it. If you take prescription medications, talk to a doctor before using skullcap.