The body makes S-adenosylmethionine, or SAMe, to drive methylation reactions that touch nearly every cell. Oral supplements use stabilized salt forms, like tosylate or disulfate p-toluenesulfonate, which absorb better and cause less stomach upset than older versions.
People mainly reach for SAMe when they want steady day-to-day mood support. Others use it for joint comfort and easier movement, though that evidence is thinner.
Take SAMe on an empty stomach. Food gets in the way of absorption. Watch out if you take anything that raises serotonin. SAMe and those drugs can stack up in ways you do not want.