Piperine, from black pepper, increases the absorption of many nutrients and supplements. People often take it with turmeric (curcumin) to raise curcumin's bioavailability. You'll also find it added to other supplements to improve their effectiveness.
Standardized piperine extract is usually taken alongside fat-soluble supplements like curcumin. It's also included in some multivitamins. Taking it with meals helps absorption.
Piperine can slow down certain liver enzymes (CYP3A4) and intestinal transporters (P-gp). This may cause higher blood levels of many prescription drugs, leading to side effects. If you use prescription medications, especially blood thinners, blood pressure drugs, or antidepressants, talk to your doctor before taking piperine. Pregnant women should avoid concentrated piperine extracts.