Naringin is a flavonoid glycoside from grapefruit and other citrus fruits. A sugar molecule makes it more water soluble than its aglycone naringenin, but that does not improve oral absorption. Most of it gets converted to naringenin by gut bacteria before reaching the bloodstream, so bioavailability is low. Researchers have looked at it as an antioxidant and for supporting heart health and blood sugar metabolism, though human evidence is still limited.
People usually take naringin in capsule or tablet form, with daily doses from 100 to 300 mg, often split into multiple servings. Since absorption is poor with or without food, you can take it at any time, but following the label directions is wise.
Naringin inhibits liver enzymes CYP3A4 and CYP2C9, which can sharply alter blood levels of many medications. This includes statins, blood pressure drugs, and some immunosuppressants. Avoid combining naringin with grapefruit juice or high-dose citrus flavonoids unless a doctor says it is safe.