The pancreas naturally releases lipase to split triglycerides from food into fatty acids the body can absorb. When the pancreas cannot produce enough, people use supplemental lipase derived from fungi or animals.
People with pancreatic insufficiency, for example from cystic fibrosis or chronic pancreatitis, often take this enzyme. Others add it as part of a digestive enzyme blend to help with fat digestion. Take it with meals, especially those containing fats.
Dosing reflects lipase units, not weight, and differs across products. Most people handle it without trouble, although high amounts may upset the stomach.