Grape seed extract concentrates the seeds of wine grapes into a supplement rich in proanthocyanidins. These antioxidant compounds support blood vessel health and help maintain normal circulation.
People take it to support cardiovascular health and joint comfort because of its antioxidant and anti-inflammatory properties. Others use it for skin health, since the compounds help protect collagen.
A common dose ranges from 100 to 300 mg of a standardized extract, taken once or twice daily. Taking it with meals helps absorption.
Caution is needed because grape seed extract can slow blood clotting. Do not mix it with anticoagulant or antiplatelet drugs like warfarin or aspirin unless a doctor supervises. It can lower blood pressure and may boost the effect of blood pressure medications, raising the risk of hypotension. Stop taking it at least two weeks before any scheduled surgery to reduce bleeding risk. Avoid it during pregnancy and while breastfeeding.