Gentian root extract is a bitter, concentrated preparation made from *Gentiana lutea*. Manufacturers standardize the extract around its bitter compounds, so tinctures and liquid drops deliver more consistent potency than whole dried root.
People use it as a digestive bitter. The sharp bitterness on the tongue sets off a reflex that increases stomach acid and bile flow right before a meal. Users typically stir a small amount into water and drink it 15 to 30 minutes before eating.
Gentian root extract is safe when you follow the directions. Avoid it if you have stomach ulcers, GERD, or frequent heartburn, since it can worsen those conditions. Do not use it while pregnant or breastfeeding.